| Login |
| Description: | Dr. Ioanna TRIVIAI Junior Group Leader - Stem Cell Biology Group Clinic of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany And Heinrich – Pette Institut, Leibniz Institute for Experimental Virology, Hamburg, Hamburg, Germany Title: "Neoplastic stem cells in hematopoietic niche disruption: the paradigm of Primary Myelofibrosis". Thursday, October 2nd 2014 @ 15:00 Seminar Room 1 [FORTH's bldg] ABSTRACT: Myeloproliferative neoplasms (MPN) are chronic hematological malignancies characterized by expansion of aberrant myeloid progenitors. Primary myelofibrosis (PMF) has the worst prognosis of all MPN and involves massive disruption of the hematopoietic niche leading to fibrosis/osteosclerosis development and/or transformation to acute myeloid leukemia (AML). In our studies to elucidate the trigerring event in PMF we identified a neoplastic stem cell population in patient peripheral blood responsible for disease initiation and development in vivo. Identifying the neoplastic stem cells in myeloproliferating neoplasms will provide the basis to decipher complicated niche interactions implicated in evolution of the chronic phase and leukemic transformation and introduce new therapeutical targets to eradicate the disease. Hosts: Dimitris Kafetzopoulos Post-Genomics Applications Lab Institute Molecular Biology & Biotechnology Emmanouil G. Spanakis, PhD. Computational Medicine Laboratory Institute of Computer Science |
| Status: | Waiting for approval |
| Date: | Thursday, October 2, 2014 |
| Time: | 15:00 EEST |
| Priority: | 5-Medium |
| Access: | Public |
| Created by: | Lila Kalogeraki |
| Updated: | Tuesday, September 30, 2014 08:52 GMT |