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[11:00] Σεμινάριο - Τμήμα Βιολογίας
- Description:
- Τίτλος: Natural selection on autosomal and X-linked genes in mice and implications for speciation genetics.
Ομιλητής: Θανάσης Κουσαθανάς
University of Edinburgh
Περίληψη: Evolutionary biologists have documented a special role of the X chromosome in speciation: loci that contribute to the evolution of reproductive isolation between species are located disproportionally on the X chromosome compared to the autosomes. An evolutionary explanation for this puzzling phenomenon has long been sought. One compelling hypothesis states that the X chromosome evolves faster than the autosomes, because new advantageous mutations are on average recessive.
According to this hypothesis, recessive mutations are exposed to selection on the X chromosome in males and are driven to fixation at a faster rate than the autosomes. To test this hypothesis, I compared the rate of adaptive substitution in autosomal versus X-linked protein-coding genes in a subspecies of the house mouse. I found that
the X chromosome does experience a faster rate of adaptive substitution than the autosomes, which is more pronounced for genes that are specifically expressed in male reproductive tissues. This finding suggests that faster-X evolution could at least partially explain the large effect of the X chromosome in speciation.
Χρόνος: Τετάρτη 26/6/2013, ώρα: 11:00 πμ
Xώρος: Αμφιθέατρο Β, Τμήμα Βιολογίας.
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Emmanuel (Manolis) LADOUKAKIS, M.Sc., Ph.D.
Department of Biology
University of Crete
Voutes University Campus
70013 Heraklio
Greece
Tel: +30 2810 394067
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June 2013
