"White Matter dysregulation and schizophrenia: recent progress"
April 30, 10:00
Seminar Room 7A.01
Panagiotis Roussos, MD PhD
Research Fellow, Department of Psychiatry
Mount Sinai School of Medicine
Responsible: Domna Karagogeos
Time:
11:00
Description:
Dr. Imre Berger
EMBL Group Leader, Grenoble Outstation
Head, Eukaryotic Expression Facility (EEF)
"MultiBac: Expanding the research tool-box for multiprotein complexes"
Monday, 13 May 2013 @ 11.00
Seminar Room No 1, 1st floor FORTH's bldg
Host: Dr. Thanasis Loukeris
Abstract:
Multiprotein complexes catalyze vital biological functions in the cell. A paramount objective of current research efforts is to address the structural molecular biology of these molecular machines, by enlisting and developing enabling technologies for their study. An emerging key prerequisite for studying complex biological specimens is their recombinant overproduction. We have designed and validated novel reagents and streamlined protocols for rapidly assembling
co-expression constructs for this purpose. The ACEMBL high-throughput pipeline for multiprotein complexes at the EMBL Grenoble is presented.
Heterologous expression of eukaryotic proteins and their complexes increasingly necessitate eukaryotic overproduction systems. Extension of the ACEMBL platform technology to eukaryotic hosts, insect cells and mammalian, has been achieved. Efficient production of large multicomponent protein complexes for structural studies using the baculovirus/insect cell system can be hampered by stoichiometric imbalance of the subunits produced. A polyprotein strategy has been developed to overcome this bottleneck and successfully implemented in our MultiBac baculovirus expression system for producing multiprotein complexes. Our technologies and their successful application to academic and industrial R&D projects, are discussed. The EC FP7
projects ComplexINC and BioSTRUCT-X for accessing our platform will be introduced.
SPEAKER: Assoc. Prof. Anna Mitraki,
Department of Materials Science and Technology,
University of Crete
and
Institute of Electronic Structure and Laser (I.E.S.L.)
Foundation for Research and Technology - Hellas (FO.R.T.H.)
TITLE: "NATURAL FIBROUS PROTEINS AS A SOURCE FOR INSPIRATION FOR THE DESIGN OF NOVEL NANO-BIOMATERIALS"
DATE: Friday 17th May 2013
TIME: 12:00
ROOM: Chemistry Seminar Room
Time:
16:00
Description:
Speaker
Eleftherios Iliopoulos
Affiliation
Department of Physics, University of Crete, Greece
Title
Novel Applications of III-Nitride Semiconductor Nanostructures
Location
Department of Physics Bldg., Voutes, 3rd floor Seminar Room
Time
16:00
Time:
14:00
Description:
Τίτλος: "Plant-insect interactions: two cases of induced systemic susceptibility".
Ομιλητής: Dr Shai Morin,
The Hebrew University of Jerusalem, Israel
O Shai Morin είναι ένας από τους πιο γνωστούς ερευνητές στον κόσμο, στο αντικείμενο της μοριακής αλληλεπίδρασης φυτών - εντόμων(whiteflies).
(http://departments.agri.huji.ac.il/entomology/staff_pages/morin.html)
Χρόνος: Παρασκευή 24/5/2013, ώρα: 14:00
Xώρος: Αίθουσα Σεμιναρίων Φυσικού (3ος όροφος)
Time:
16:00
Description:
Speaker
Helen A. Papadaki
Affiliation
University of Crete School of Medicine
Head of the Department of Haematology, University Hospital of Heraklion
Title
Mesenchymal stem cells and their applications in Regenerative Medicine
Location
Department of Physics Bldg., Voutes, 3rd floor Seminar Room
Time
16:00
Abstract
Embryonic stem cells can differentiate into cells of all three germ layers whereas adult stem cells have been traditionally considered to display a limited differentiation potential. Recently, however, a type of adult stem cells namely the mesenchymal stem cells (MSCs), have been emerged as a major breakthrough in regenerative biology. MSCs can be isolated from a variety of tissues including the bone marrow, adipose tissue and umbilical cord among others, and display the capacity to differentiate into different cell types of ectodermal, endodermal and mesodermal origin. MSCs have been therefore
used in preclinical trials for tissue engineering of bone, cartilage, muscle, marrow stroma, tendon, fat, and other connective tissues. MSCs
also secrete a large spectrum of bioactive molecules with immunosuppressive and immunoregulatory properties providing a regenerative microenvironment with nursing and nourishing potential.
Overall, MSCs appear to be valuable tools for tissue repair and regeneration. A number of human clinical trials are now under way using allogeneic MSCs for bone and cartilage repair and treatment of myocardial infarction, stroke, spinal cord injury, graft-versus-host disease and autoimmune diseases. Tissue engineering and MSC-based scaffold technology represents also an emerging, promising field of research in regenerative medicine.
Time:
16:00
Description:
Speaker
Maria Chatzinikolaidou
Affiliation
Department of Materials Science and Technology,
University of Crete, Greece
Title
Development of biomaterials for bone tissue repair
Location
Department of Physics Bldg., Voutes, 3rd floor Seminar Room