Abstract
Modern advances of photonic technologies and their application in
biomedical research and clinical practice have raised immense interest
in the scientific community. It is only recently that the Nobel Prize
was awarded for the invention of Nanoscopy and breaking one of the
fundamental laws of optics. We are now able to observe and quantify
biology with resolutions down to the nanometer scale. At the same time
the field of in vivo molecular imaging is being widely recognized as one
of the most influential for translational research, transforming health
care and personalized approaches for diagnosis and therapy. In that
respect, current tools in biophotonics have offered a new avenue for
exploration of biological function, detection and treatment of disease
in living organisms and systems.
Methods that provide three dimensional microscopic images such as
Optical Projection Tomography (OPT) and Light Sheet Fluorescence
Microcopy (LSFM) or Selective Plane Illumination Microscopy (SPIM) have
found their way into biology labs due to their advantages compared to
traditional methods such as confocal microscopy in imaging larger
samples. On the other hand, recent advances in optoacoustic imaging have
allowed to image in so far non-accessible regimes with unprecedented
resolutions, based on the use of light for the illumination and
production of ultrasonic waves. These developments have provided the
means for performing high resolution, quantitative, volumetric and
dynamic studies in live specimens ranging from imaging the development,
to imaging cancer, the function of the cardiovascular system, to
neuroimaging, aging and associated diseases to chemotherapeutic
interventions and drug delivery. Moreover, they offer to users unique
capabilities for basic studies and most importantly for detecting and
treating major diseases in clinical practice alongside or replacing
established methodologies .
However, the use of photonic technologies, even though exhibiting very
important advantages and offering insight in new bio-molecular
functions, still comes with significant disadvantages associated with
the diffusive transport of light in biological tissue. Radically new
technologies though are being developed for the production, manipulation
and delivery of light radiation, based on adaptive wavefront control and
shaping to compensate for light diffusion and overcome the limitations
of conventional microscopy and obtain high resolution images deeper than
a few micrometers.
These very exciting discoveries and advances in biophotonic technologies
have now starting to revolutionize the way biological research is
performed. The ability to perform in vivo imaging in scales ranging from
microscopy to macroscopy at depth from a few micrometers to several
centimeters opens up the possibility to shift biological observation
towards longitudinal noninvasive studies of dynamic phenomena inside
whole animals and help understand better human development, function and
disease.
J. Sharpe, et al, Science 296, 541-545 (2002)
M. Rieckher, et al, PLOS One, 10, e0127869 (2015)
R. Weissleder, & M. J. Pittet, Nature 452, 580-589 (2008).
Abstract:
A combination of ab-initio, Monte Carlo and Molecular Dynamics techniques is used for designing novel nanoporous materials for various
applications. Hydrogen, methane and CO2 storage, natural gas processing, drug delivery
and flexible electronics are some of the tasks that will be addressed
and their connection to nanoporous materials will be analyzed. Different type of strategically designed novel nanoporous materials like: Nanotube and Molecular Pillared Graphene [1], Porous Nanotube Networks [2], Super Diamond, Metal and Covalent Organic Frameworks [3-4], will be presented and their structural and electronic properties
will be discussed. In addition, the root for the improvement of materials' properties with molecular engineering will be also
demonstrated [5]. Finally, a new computational methodology for large-scale screening of
materials with the use of Machine Learning algorithms (ML) will be introduced [6].
References
[1] “Pillared Graphene: A New 3-D Network Nanostructure for Enhanced
Hydrogen Storage” Dimitrakakis, G. K.; Tylianakis, E.; Froudakis, G.
E. Nano Letters 8 (2008) 3166-3170.
[2] “Porous nanotube network: a novel 3-D nanostructured material with
enhanced hydrogen storage capacity” E. Tylianakis, G. Dimitrakakis, S.
Melchor, J.A. Dobado and G.E. Froudakis, Chem. Commun., 47(2011)2303-2305.
[3] "Designing 3-D COFs with enhanced hydrogen storage capacity." E. Klontzas, E. Tylianakis, G.E. Froudakis, Nano Letters, 10 (2010) 452–454.
[4] “Improving Hydrogen Storage Capacity of MOF by Functionalization of the Organic Linker with Lithium Atoms.” Klontzas, E.; Mavrandonakis,
A.; Tylianakis, E.; Froudakis, G. E. Nano Letters 8 (2008) 1572- 1576.
[5] “Enhancement of hydrogen adsorption in Metal-Organic Frameworks by
the incorporation of the sulfonate group. A multiscale computational study”, A. Mavrandonakis, E. Klontzas, E. Tylianakis, G.E Froudakis, J. Am. Chem. Soc., 131 (2009) 13410–13414.
[6] “Chemically intuited, large-scale screening of MOFs by machine learning techniques”, Borboudakis, G; Steriannakos, T; Frysali, M;
Klontzas, E.; Tsamardinos, I; Froudakis, G.E.;, Nature Computational Materials 40 (2017) xxx-xxx.
Host: Anna Mitraki 4095
Time:
16:30 - 17:30
Location:
Physics Dept. 3rd-floor seminar room
Description:
Atomic Molecular and Optical Physics Seminar
Reaction Product Imaging: Chemistry in Quantum Detail
Dr. Petros Samartzis - FORTH-IESL
Faculty coordinator of ERASMUS+
Research group of cardiovascular and respiratory pharmacology and toxicology (head)
Department of Pharmacology and Toxicology Faculty of Pharmacy in Hradec Králové, Charles University Hradec Kralove, Czech Republic.
www:http://portal.faf.cuni.cz/Profile/Mladenka-Premysl/?lang=en-GB
TITLE: “Cardiovascular effects of flavonoids”
DATE: Monday, 13 November 2017
TIME: 14:00
ROOM: Chemistry Seminar Room
Prof. Mladěnka will give a short presentation about the Faculty of Pharmacy, Charles University
and possibilities for ERASMUS+ study or fellowships
Then, he will make an introduction to TOX-OER (Learning Toxicology through Open Educational Resources) project.
Abstract
Natural processes of photosynthesis have increasingly inspired the
fabrication of nanostructured molecular materials with advanced
light-harvesting and electron-transfer features. [1-6] In this context,
supramolecular chemistry allows diverse and disparate molecular building
blocks to be amalgamated into highly ordered architectures. These mimics
the key functions of the photosynthetic reaction center; light
harvesting, charge separation, charge transport, and catalysis. [7,8]
Porphyrinoids, the basic building block of chlorophylls, have emerged as
an exceptional class of light harvesters and electron donors in such
supramolecular electron donor-acceptor hybrids [9-12].
References:
1. M. R. Wasielewski, Chem. Rev., 1992, 92, 435-461.
2. R. E. Blankenship, Molecular Mechanisms of Photosynthesis, Blackwell
Science, Oxford, U.K., 2002.
3. D. Gust, T. A. Moore and A. L. Moore, Acc. Chem. Res., 1993, 26,
198-205.
4. H. B. Gray and J. R. Winkler, Annu. Rev. Biochem., 1996, 65, 537-561.
5. M. Grätzel, Journal of Photochemistry and Photobiology C:
Photochemistry Reviews, 2003, 4, 145-153.
6. T. Nakanishi, Supramolecular Soft Matter, Applications in Materials
and Organic Electronics, John Wiley &Sons, New Jersey, 2011.
7. D. M. Guldi, Chem. Soc. Rev., 2002, 31, 22-36.
8. F. D’Souza, Handbook of Carbon Nanomaterials, Synthesis and
Supramolecular Systems, World Scientific Publishing Co. Pte. Ltd,
Singapore, 2011.
9. Manas K. Panda, Kalliopi Ladomenou, and Athanassios G. Coutsolelos,
Coordination Chemistry Reviews 21-22, 2601-2627.
10. K. Ladomenou, M. Natali, E. Iengo, F. Scandola, G. Charalampidis,
A. G. Coutsolelos Coordination Chemistry Reviews, 2015, 38-54.
11. C. Stangel, C. Schubert, S. Kuhri, G. Rotas, J.T. Margraf, E.
Regulska, T. Clark, T. Torres, N. Tagmatarchis, A. G. Coutsolelos, D. M.
Guldi. Nanoscale 2015, 7, 2597-2608.
12. V. Nikolaou, K. Ladomenou, G. Charalambidis, A. G. Coutsolelos,
Coordination Chemistry Reviews, 2016, 1-42
Host: Anna Mitraki 4095
Time:
16:00
Description:
Speaker: Dr. Efstathios Kaliviotis
Affiliation: Department of Mechanical Engineering and Materials Science
and Engineering, Cyprus University of Technology,
Dept. of Mechanical Engineering, University College London, UK
Title: “Blood rheology and flow characteristics in the macro- and
micro-scale”.
Abstract
Blood can be considered as a two phase, non-Newtonian fluid, and its
flow characteristics, in particular in the microvasculature, are
affected by this fact. To a large degree the complex mechanical nature
of the fluid is due to red blood cell (RBC) aggregation phenomenon,
which is found intense in a number of pathological conditions. The time
and flow-dependent characteristics of the aggregated structures
developed in blood affect its mechanical properties, and can be examined
by various techniques. In this talk the influence of RBC aggregation on
blood rheology at the macroscale will be discussed first. It will be
shown that secondary aggregation characteristics may play a key role in
explaining the behaviour of the mechanical properties of the fluid under
various flow conditions. Secondly, the influence of the RBC aggregation
phenomenon on the flow characteristics for microscale bifurcating
geometries, resembling the microvasculature, will be discussed. It will
be illustrated that the aggregation phenomenon, apart from the flow
characteristics, affects the aggregate distribution in the bifurcation
in a counterintuitive manner, i.e. the smaller aggregates appear in
regions of lower shear, as opposed to the general understanding that
aggregation increases at the specific shear conditions. Such behaviour
is explained when considering the spatial distribution of aggregates in
conjunction to the velocity field developed in the parent channel
branches. Finally, an attempt to predict the local viscosity in the
microchannels will be described based on existing constitutive equations
for blood.
Το Ινστιτούτο Μεσογειακών Σπουδών/ΙΤΕ
σας καλεί στη διάλεξη της Ευγενίας Ρούσσου,
με θέμα Από το 'κακό μάτι' στις ενεργειακές θεραπείες: μια εθνογραφική προσέγγιση των πρακτικών εναλλακτικής ιατρικής στην Ελλάδα της κρίσης.
Πέμπτη, 23 Νοεμβρίου και ώρα 20.30
Αίθουσα Διαλέξεων ΙΜΣ, Νικηφόρου Φωκά 130, Ρέθυμνο
Από το 'κακό μάτι' στις ενεργειακές θεραπείες: μια εθνογραφική προσέγγιση των πρακτικών εναλλακτικής ιατρικής στην Ελλάδα της κρίσης.
Ευγενία Ρούσσου, Συνεργαζόμενη Ερευνήτρια, Κέντρο Έρευνας της Ανθρωπολογίας, Νέο Πανεπιστήμιο Λισαβόνας
Στην σημερινή Ελλάδα, ο αριθμός των ατόμων που καταφεύγουν σε ενεργειακές θεραπείες για να αντιμετωπίσουν προβλήματα όσον αφορά στην υγεία και την ευημερία τους συνεχίζει να αυξάνεται. Από γιόγκα και διαλογισμό ως (νεο)σαμανισμό και θεραπευτικές πρακτικές που βασίζονται σε πνευματικές παραδόσεις της Ασίας, της Βραζιλίας και της Αφρικής, υπάρχουν πλέον πολλές επιλογές ως προς το ποια θεραπευτική πρακτική μπορεί κανείς να υιοθετήσει στην καθημερινότητά του, συμπεριλαμβανομένης και της πιο ‘παραδοσιακής’ θεραπείας ενάντια στο ‘κακό μάτι’. Βασισμένη σε ανθρωπολογική έρευνα που έχει διεξαγάγει η ομιλήτρια στο Ρέθυμνο και την Αθήνα, η διάλεξη θα επικεντρωθεί στην παρουσίαση του πλουραλιστικού αυτού κοινωνικοπολιτισμικού πλαισίου των θεραπευτικών πρακτικών της λεγόμενης εναλλακτικής ιατρικής και τη σύνδεσή του με τις κοινωνικο-οικονομικές προκλήσεις που αντιμετωπίζουν σήμερα οι χώρες της Μεσογείου. Στόχος είναι να δοθεί μια εθνογραφική εικόνα για τον ποικιλόμορφο, πολυδιάστατο και πολυπολιτισμικό χαρακτήρα των εναλλακτικών θεραπειών στην Ελλάδα και να αναλυθεί το πώς ακόμα και πιο ‘παραδοσιακές’ θεραπευτικές πρακτικές, όπως αυτή του ξεματιάσματος, έχουν αρχίσει να προσαρμόζονται εκ νέου και να υποβάλλονται σε μια διαδικασία μεταμόρφωσης, προκειμένου να προσαρμοστούν στα νέα δεδομένα διαχείρισης της ιδιωτικής και δημόσιας υγείας στην Ελλάδα της κρίσης.
Time:
12:00 - 13:00
Location:
“Seminar Room 1”, FORTH’s bldg
Description:
IMBB SEMINAR
Giorgos HAMILOS, MD
Associate Professor
Director of Clinical Microbiology
and Micorbial Pathogenesis Lab
School of Medicine, Univesity of Crete
Title: "Dissecting molecular pathways regulating biogenesis of the fungal phagosome"
Yield-stress fluids are soft solids when subjected to a shear stress lower than their yield stress, but flow in response to higher stresses.
I will discuss the process by which Carbopol, a model yield-stress fluid, changes from solid-like to fluid-like when it starts to flow in a
vertical pipe. In a rough-walled pipe, the yielding involves a long transition with several steps: elastic deformation, the onset of wall
slip, yielding at the wall, and finally a steady-state plug flow that is well-described by the predictions of the Herschel-Bulkley model. I will then discuss experiments on the flow of Carbopol confined to square microchannels with sides ranging from 500 µm down to 50 µm. In the
larger channels, measured velocity profiles agree well with simulations based on the bulk rheology of the Carbopol and the Herschel-Bulkley model. In contrast, in microchannels smaller than 150 µm the velocity profiles could not be fitted by a model with a finite yield stress, but instead were described by a power-law model with zero yield stress. I will discuss the vanishing of the yield stress in terms of the effect of confinement on the microstructure of the Carbopol.
Host: Dimitris Vlassopoulos 1469
Time:
12:00 - 13:00
Location:
“Seminar Room 1”, FORTH’s bldg
Description:
IMBB SEMINAR
Michalis KOTSYFAKIS
Head of the Laboratory of Genomics and Proteomics of Disease Vectors,
Biology Center of the Czech Academy of Sciences,
Budweis, Czech Republic
Title: "The tick Ixodes ricinus as a model organism for discovering potent pharmacological activities"
Το Τμήμα Χημείας του Πανεπιστημίου Κρήτης διοργανώνει το Σάββατο 2 Δεκεμβρίου 2017, για πέμπτη συνεχόμενη χρονιά, Ημερίδα Χημείας στην οποία συμμετέχουν καθηγητές, μεταπτυχιακοί φοιτητές και υποψήφιοι διδάκτορες, αφιερωμένη στη μνήμη της αξέχαστης Δρ. Μαρίας Χατζημαρινάκη.
Η ημερίδα περιλαμβάνει ομιλίες σε σύγχρονα θέματα χημείας με μεγάλο ερευνητικό αλλά και πρακτικό ενδιαφέρον. Το πρόγραμμα της ημερίδας ολοκληρώνεται με την βράβευση ενός μεταπτυχιακού φοιτητή για εξαίρετη πορεία στις μεταπτυχιακές σπουδές. Το βραβείο συνοδεύεται και από χρηματικό έπαθλο, το οποίο ευγενώς προσφέρεται από την οικογένεια της Μαρίας Χατζημαρινάκη.
ΗΜΕΡΟΜΗΝΙΑ: Σάββατο, 2 Δεκεμβρίου 2017
ΩΡΑ: 9:30 πμ
ΑΙΘΟΥΣΑ: Αίθουσα σεμιναρίων Χημείας
Παρακαλούμε δείτε το σχετικό αρχείο:
http://news.uoc.gr/news/2017/29-11/ΠΡΟΓΡΑΜΜΑ.5ης.Ημερίδας.Χημείας.2017.pdf